Nordic Cryobank Group ApS - NCB - (European Sperm Bank) - 8040/ADLER
To the Federal Office for Safety in the health care was given from the Danish authority informed thatthey from the Danish tissue bank Nordic Cryobank ApS - NCB - (European Sperm Bank) via a microduplication in the PAR1 region Xp22.33/Yp11.32 at the sperm donor 8040/ADLER informed has been.
The duplication was by means of Multiplex Ligation-dependent Sample Amplification(MLPA; probemix P018-G1 SHOX, MRC-Holland) verified.
The duplication includes not the SHOX gene, but is located is located downstream in the regulatory region.
Duplications in this region will be with symptoms of the Dyschondrosteosis Léri Weill / Skeletal dysplasia or Idiopathic Short stature (Idiopathic short stature - ISS) associated, find can be found but can also be found in individuals of normal stature.Children of this donor have a 50 % risk this duplication to inherit.
Since not established has been whether itself the duplication in the PAR1 region of the X or of the Y chromosome is located, both male and female children can inherit both male and female children can inherit this duplication.
According to statement the Danish tissue bank was the donor with the Identification 8040/ADLER permanent locked and his donation material may not longer used be used.All clinical users, which the Sperm Donation of this donor received have have been according to statement the Danish Tissue Bank formal per mail or by email, with the reference this donor to block, informs. Sperm donation from this donor (incl. embryos) may further for parents, who already a child of this donor have used be - this however exclusively at the condition, that the parents in writing informed were and the risk confirmed accept
